Dr. M. Kaleemullah Khan and Mohd Nasir Mohiuddin
Introduction: End stage renal failure eventually develops in 40% of patients with diabetes, the IDDM constitute the single most usual disease leading to inadequacy in adults. Patients with type 2 diabetes had higher HBA1c and FBS together that is distinctly reduced the reactiveness of insulin in contrast to healthy control subjects. On average, death takes place 7years after the start of persistent proteinuria but the scale is wide (2-32) years. Even though morphological bruises advance and nature in glomeruli of those that with diabetes after a few years of metabolic deformities.Chronic hyperglycemia as measured by mean blood glucose or HBA1c has been associated with the development and advancement of micro vascular diabetic complications.
Methodology: This is a case control study done in the in-patient department of general medicine. From January to July 2014. The patients selected has a history of diabetes for more than 3 years and were on hypoglycemic agents/insulin. Diabetic nephropathy was confirmed by elevated levels of blood urea and serum creatinine, which has the level above 6.5 mg/dl. All patients had persistent increase in serum creatinine examinations and controlled cases are selected contingent on their normal creatinine and urea excretion profile.
Results: the mean age of the patients with diabetic nephropathy is 54.43 ± 7.99 while the mean age of patients with control profile of diabetes were 48.37 ± 6.99. There were 22.9%, almost 23% of the patients with diabetic nephropathy are anemic. And the mean FBS levels in diabetic nephropathy in the current study were about180. 85 ± 42.05 and the mean exhibit by control groups 81.4 ± 7.0. While the mean HBA1C range in diabetic nephropathy patients was about 9.96 ± 5.07 and 4.45 ± 0.57 is the mean of the control group. The levels of blood urea, serum creatinine and triglycerides are evidently high,though which when compared to control group.
Conclusion: HBA1c and FBS are the important predictors of intercapillary glomerulonephritis or diabetic nephropathy. HBA1c is highly co-related to preceding mean blood glucose. The chief outcome measures which predicts the intercapillary glomerulonephritis or diabetic glomerulosclerosis or diabetic nephropathy are HBA1c, triglycerides, serum creatinine and blood urea nitrogen. Patients with progressed nephropathy showed increased levels of serum triglycerides, which is the important independent clinical attribute.
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