American Journal of Advanced Drug Delivery Acesso livre

Abstrato

Anticonvulsant Activity of Ethonolic Extract of Nyctanthes arbor-tristis in Albino Mice

Cuddapah Rajaram, Kandula Ravindra Reddy, Kothapalli Bonnth Chandra Sekhar and Rakhal Chandra Da

Objective: The main objective of the present study was to assess the anticonvulsant activity of ethonolic extract of Nyctanthes arbortristis (ENA) in albino mice.

Method: The anticonvulsant activity of ethanolic extract of Nyctanthes arbor-tristis (200 and 400 mg/kg, P.O) was assessed in pentylenetetrazole (PTZ) and maximal electroshock (MES) induced convulsions in albino mice. Onset of convulsion, duration of convulsion, tonic extension phase, and mortality were noted in the present study. The antioxidant property was evaluated by measuring the lipid peroxidation (LPO) and reduced glutathione (GSH).

Results: In the pentylenetetrazole induced convulsion, ethonolic extract of Nyctanthes arbor-tristis (400 mg/kg, P.O) significantly delayed the onset of convulsion, reduced the duration of convulsion (p<0.05) and reduced mortality. The ethonolic extract of Nyctanthes arbor-tristis at (400 mg/kg, P.O) reduced hind limb tonic extension phase in maximal electroshock induced convulsion in albino mice (p<0.05). The pre-treated ethonolic extract of Nyctanthes arbor-tristis showed significant antioxidant property by inhibition of lipid peroxidation and increases the reduced glutathione level in mice brain tissue (p<0.001).

Conculsion: In conclusion the results indicated that Nyctanthes arbor-tristis possesses a significant dose dependent anticonvulsant activity.