Jornal de Biomarcadores Acesso livre

Abstrato

Decrease of Patients with Brain Infarction through Evaluation of Relative Risk Value of Brain Infarction by Measurement of Protein-Conjugated Acrolein, IL-6 and CRP in Plasma Together with Age

Takeshi Uemura, Tetsuto Kanzaki, Katsuhiko Ishizawa, Keiko Kashiwagi, Kazuei Igarashi

Background: The Relative Risk Value of Brain Infarction (RRVBI) estimated by measuring protein-conjugated acrolein (PC-Acro), interleukin-6 (IL-6) and C-reactive protein (CRP) in plasma together with age finds silent (small) brain infarction (SBI) with 84% sensitivity and specificity. The purpose of this study is to evaluate the effect of RRVBI estimation on the disease onset probability of brain infarction. Methods: The number of patients with brain infarction was evaluated among the workers belonging to a union of the similar business health insurance. Results: The number of disease onset patients with brain infarction gradually decreased after the adoption of RRVBI during 7 years evaluation. Finally, the number of disease onset patients with brain infarction decreased to less than 35% compared with the number before the adoption of RRVBI. Conclusion: Our results suggest that RRVBI contributes to maintenance of quality of life (QOL) for the elderly.