Vinay Umesh Rao, E. Sangeetha, M. Sudhakar
The effect of three different viscosity grades on the in vitro dissolution profile of Aripiprazole controlled release tablets was studied. The study was carried out using full factorial design of experiments. The release rate of 5 to 6 mg%/ hour was targeted and the effect of the polymers on drug release over 24 hours was evaluated at the total polymer level between 30% and 45%. The DOE experiments have shown that when the combination of polymer is used, the total polymer concentration should be in a narrow range of 32.4% w/w to 37.5% w/w in order to achieve the target dissolution profile.
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