Usama Khalid Choudry
Borderline Personality Disorder is a psychiatric disorder with complex underlying neurophysiology. Reviewing various literatures we came to understand that BPD is characterized by impulsive, aggressive, suicidal, self-inflicted harmful behaviors. Even though conventional theories ascribe to environmental etiologies (negative events such as childhood abuse and trauma). Genetic vulnerability disposes as one of the main factors which alter the neurophysiology of BPD patients. There is highly supportive evidence regarding the abnormalities of frontolimbic neuronal information processing, low cerebral serotonin states owing to dysfunction of serotonin genes, autonomic dysregulation in the context of poly vagal theory and cortical inhibition deficiency contributing towards symptomology and behavioral patterns of BPD patients.
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