R. Saravanan, P. Ramasamy, S. Sudharsan, S. Vairamani and A. Shanmugam
Rats (140 ± 20 g) were divided into four groups (n=6); control (Group I), ISO Group II (85 mg/kg of ISO subcutaneously injected at 13th and 14th days), GAG treated (300 μg/day per rat s. c. for 2 weeks - Group III), and GAG plus ISO Group IV (300 μg/day per rat s. c. for 12 days and then by ISO on 13th and 14th days). At the end of experimental period, all rats were anesthetized with sodium pentabarbitol and sacrificed by survical decapitation. Plasma, serum and heart tissues were separated for enzymes assays. Lactate dehydrogenase (LDH), aminotransferases (AST and ALT) and creatine kinase (CK) activities were increased in serum and decreased in heart tissue of ISO group, which were normalized by GAG pretreatment rats. Superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) activities and reduced glutathione (GSH) were abnormal in the ISO induced rats, and this was minimized by GAG pretreatment. Increased level of thiobarbituric acid reactive substances (TBARS) in plasma and the heart of ISO treated rats; pre s.c. injected with GAG to ISO-induced rats decreased the levels of TBARS. Restoration of cellular normalcy accredits GAG has protective role against ISO-induced cardiotoxicity.
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