Jornal de Autacóides Acesso livre

Abstrato

Targeting Neutrophil Apoptosis for Enhancing the Resolution of Inflammation

János G. Filep

Resolution of acute inflammation is a full of life method that needs inhibition of additional corpuscle accomplishment and removal of leukocytes from inflamed sites. Emigrated neutrophils endure cell death before being removed by scavenger macrophages. Recent studies employing a style of factor knockout, transgenic and pharmacologic methods in numerous models of inflammation established leukocyte cell death as a important management purpose in breakdown inflammation. Analysis of death mechanisms disclosed distinct options in execution the death program in neutrophils, which may be exploited as targets for dominant the period of time of neutrophils. Indeed, medication and pro-resolution supermolecule mediators derived from essential fatty acids, like lipoxin A4 and resolvin E1, autacoids and proteins, like annexin A1 and path, and cyclin-dependent enzyme inhibitors, will enhance the resolution of inflammation through induction of leukocyte cell death and promoting their removal by efferocytosis. during this review, we have a tendency to discuss recent advances in understanding the molecular basis of those actions, lightness the potential of therapeutic induction of leukocyte cell death for moistening neutrophil-mediated tissue injury and inflammation underlying a spread of diseases.