Revista de Cardiologia Intervencionista Acesso livre

Abstrato

VEGF Polymorphisms do not contribute to the risk of congenital heart defect

Weiyan Zhang, Xuming Mo, Di Yu, Changfeng Fan, Zhongyuan Wen, Liang Hu and Ming Xu

Objective: To clarify the role of VEGF polymorphisms in CHD, we performed a meta-analysis to determine the association between these three variants and risk of CHD.

Methods: Our meta-analysis included a total of 6, 4, and 6 research articles for each of the C2578A, G1154A, and G634C polymorphisms, respectively. Data extraction and study quality assessment were performed in duplicate. Summary odds ratios (ORs) and 95% confidence intervals (CIs) of allele contrast and genotype contrast were estimated using either a fixed or random effects model. The Q-statistic test was used to identify heterogeneity and a funnel plot was adopted to evaluate publication bias.

Results: Six articles containing 1080 cases and 2289 controls were relevant to C2578A, 4 researches containing 528 cases and 1036 controls were relevant to G1154A, and 6 articles containing 1081 cases and 2281 controls were relevant to G634C. The results of overall meta-analysis showed that none of the VEGF C2578A, G1154A, G634C increased the susceptibility of CHD. In summary, this meta-analysis demonstrates that the three analyzed VEGF polymorphisms do not increase the risk of CHD.

Conclusions: Our meta-analysis suggests that the common VEGF polymorphisms C2578A, G1154A, and G634C do not alter CHD risk.