Jana Janovska, Julia Voicehovska, Violeta Fodina and Elina Zandberga
Introduction: During skin aging, cumulative photo damage, exhaustion of endogenous stem cell populations, mechanical stress, and increased fibrosis lead to skin with decreased epidermal thickness and compromised dermal integrity (Maciej Nowacki et al, 2018). Stem cell-based therapies have been widely used for their abilities to repair and regenerate different types of tissues and organs in cosmetic and plastic surgeries. Despite the fact, that most treatments involving stem cells are new and have very little evidence based efficacy, stem cell treatments for skin rejuvenation are already being hailed as the preferred method by which to perform a facelift non-surgically (Odunze M et al 2011). Mesenchymal stem cells (MSCs) seem to be an ideal source for tissue engineering application due to the lack of ethical concerns, high availability and increasing number of methods for isolation and expansion of such cell types (Davood Mehrabani et al).
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