Mohan Rao Guguloth, Samba Naik Angothu, Sreedhar Surampudi and Jagadish Naik Mude
In the present study oral administration of aqueous extract of Sapindus saponaria (SS) to streptozotocin (STZ) induced diabetic rats secluded the rats from the changes induced in carbohydrate and lipid metabolism. The increase in the glycosalated hemoglobin is a sign of succession in diabetes. In addition during diabetes there is an enhancement in the cholesterol and triglyceride contents. The Supplementation of Sapindus saponaria leaves aqueous extract (100mg/kg bw) brought the levels of glucose (98±8.4) and lipids (LDL: 32.14±2.71 b and VLDL: 25.71±1.86 b) to almost normal by demonstrating anti-hypoglycemic and anti-lipidemic properties. The reduction in HDL cholesterol in diabetic rats can be used as a marker in the evaluating the severity of diabetes.
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