Jornal Europeu de Biologia Experimental Acesso livre

Abstrato

Evaluation of anticarcinogenic activity of Clerodendrum serratum leaf extract on liver and kidney of 7, 12-dimethylbenz[a]anthracene (DMBA) induced skin carcinogenesis in mice

Jayaraj. F. Chinchali, Rajeshwari. D. Sanakal and Basappa. B. Kaliwal

The evaluation of the anticarcinogenic activity of the Clerodendrum serratum leaf extract (CSLE) on liver and kidney of 7, 12-dimethylbenz[a]anthracene (DMBA) induced skin carcinogenesis in mice were studied. Group I served as control. The skin lesions were induced by twice-weekly topical application of DMBA for two weeks on the shaved backs of group II, III, IV and V mice. CSLE was administered to group III, IV and V mice at the dose of 300, 600 and 900 mg/kg b.wt/day, for 4 week before DMBA application, and continued till 45 days. On 46th day the mice were sacrificed, liver and kidney were dissected out freed from adherent tissue and weighed to nearest milligram and evaluated the effect of administration of CSLE on biochemical and oxidative stress parameters. Our findings showed that there was a recovery in biochemical and oxidative stress parameters in the liver and kidney of the CSLE administered mice. Together, these findings suggest that Clerodendrum serratum leaf extract has anticarcinogenic efficacy against skin carcinogenesis.