Yogesh S.Katare*, Santosh S. Bhujbal, Anand R. Bafna, Somashekar S. Shyale, Maruti K. Shelar, Sagar D. Kadam, Dhananjay A. Landge and Darshan V. Shah
In present modern life style anxiety is the most frequent psychiatric condition in majority of population and this become important area of research in psychopharmacology so it is now contemporary to search some safe and effective alternative. Keeping this view in mind the present study was undertaken to investigate the anxiolytic effect of polyherbal formulation and synergism between compounds present in formulation. Formulation consists of hydrolacoholic extract of Centella asiatica, Withania somnifera and Ocimum sanctum all of which are classified in Ayurveda as rasayanas which are reported to promote physical and mental health. Individual extracts and formulation were screened for phytochemical investigation and anxiolytic action in mice. Phytochemical tests were carried out by using standard reported methods which revealed the presence of desired phytoconstituents for anxiolytic action. In elevated plus maze model and Light/dark exploration model, formulation has revealed the significant anxiolytic activity at 200 mg/kg. Formulation has shown potent activity than individual plant extracts. Thus present study revealed that formulation showed anxiolytic activity and this may be due to synergism between Centella asiatica, Withania somnifera and Ocimum sanctum.
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