Maryam Darabi and Samin Seddigh
Isoprenoids are synthesized by condensation of two C5 units’ isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR, EC 1.1.1.34) catalyzes the conversion of HMG-CoA to mevalonate, which is the first committed step in the pathway for isoprenoid biosynthesis. In this study, we did bioinformatics analyses on 12 HMGR protein sequences in six different organisms including Arabidopsis thaliana, Drosophila melanogaster, Gossypium hirsutum, Homo sapiens, Mus musculus and Oryza sativa by computational tools to predict the phylogenetic relationship. Sequence comparison analysis revealed there is a high identity between them and phylogenetic analysis indicated that there is a relationship among species of different organisms. According to these results, HMGRs should be derived from a common ancestor.
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