Fatemeh Mohammadi Fartkhooni , Ali Noori , Monireh Momayez , Leila Sadeghi, Kobra Shirani and Vahid Yousefi Babadi
Nanoparticles have widespread application in all aspects of modern life because of unique features of their as small size and high surface area. Their features especially high surface area cause it is very reactive and toxic. They can damage human and animal cells by increasing oxidative stress mechanism. Nanotitanium dioxide (TiO2) having different capabilities such as robust oxidation, biocompatibility, photocatalytic properties frequently used in a wide range of sciences, including pharmaceuticals, cosmetics, medicine and engineering. Wide application of this materials resulted wide exposing of human and animals to this, so analysis of its toxicity and distribution in the body is important. This study investigates the effects of TiO2 nanoparticle on the concentration of sexual hormones such as LH, FSH and testosterone. Results showed significant alteration in LH and Testosterone concentration, but histological studies doesn’t show any important changes in testis tissue, count of Spermatogonia, spermatocytes and spermatid that is interestingly different from other study.
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